Caerulomycin A

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$4125	Check With Us
200mg	$6180	Check With Us
500mg	$15640	Check With Us

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Cat #: V4052 CAS #: 21802-37-9 Purity ≥ 98%

Description: Caerulomycin A (also known as Cerulomycin, CaeA) is a novel bipyridyl compound that induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling.

References: Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	229.23
Molecular Formula	C12H11N3O2
CAS No.	21802-37-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 150 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	COC1=CC(C2=NC=CC=C2)=NC(/C=N/O)=C1
Synonyms	NSC-114341; NSC114341; NSC 114341; Carulomycin A; AC1NTHG8; AC1N-THG8; AC1N THG8; HE185727; HE 185727; HE-185727

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.3624 mL	21.8122 mL	43.6243 mL	87.2486 mL
5mM	0.8725 mL	4.3624 mL	8.7249 mL	17.4497 mL
10mM	0.4362 mL	2.1812 mL	4.3624 mL	8.7249 mL
20mM	0.2181 mL	1.0906 mL	2.1812 mL	4.3624 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.