Cabozantinib malate (XL184)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $400 | Check With Us |
| 5g | $750 | Check With Us |
| 10g | $1125 | Check With Us |
: Cat #: V0526 CAS #: 1140909-48-3 Purity ≥ 98%
Description: Cabozantinib malate (formerly known as XL-184 or BMS-907351; trade name Cometriq) is the malate salt form of Cabozantinib, a novel, potent and orally bioavailable VEGFR2 inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 635.59 |
|---|---|
| Molecular Formula | C28H24FN3O5.C4H6O5 |
| CAS No. | 1140909-48-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (157.3 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 15mg/mL |
| SMILES Code | COC1=CC2=C(OC3=CC=C(NC(C4(C(NC5=CC=C(F)C=C5)=O)CC4)=O)C=C3)C=CN=C2C=C1OC.O=C(O)[C@@H](O)CC(O)=O |
| Synonyms | Cabozantinib malate; XL-184; BMS-907351; XL184; XL 184; BMS907351; BMS 907351; Cabozantinib S-malate. Brand name: Cometriq. |
| Protocol | In Vitro | Cabozantinib (0.1-0.5μM) inhibits the constitutive and inducible MET phosphorylation and its resultant downstream signaling in all MPNST cells. Cabozantinib (> 0.1μM) elicits a significant MPNST cell growth inhibition; higher Cabozantinib doses are needed to inhibit NSC growth. Cabozantinib treatment blocks HGF-induced MPNST motility and invasion (a similar effect of found on NSC). |
|---|---|---|
| In Vivo | Cabozantinib (60 mg/kg, i.p.) decreases the tumor vascularity with reductions ranging from 67% at 3 mg/kg to 83% at 30 mg/kg for 7 days in animals. Tumors in RIP-Tag2 mice treated for 7 days beginning at age 10 weeks are 40% smaller after XL880 and 35% smaller after Cabozantinib, compared to corresponding values for vehicle. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5733 mL | 7.8667 mL | 15.7334 mL | 31.4668 mL |
| 5mM | 0.3147 mL | 1.5733 mL | 3.1467 mL | 6.2934 mL |
| 10mM | 0.1573 mL | 0.7867 mL | 1.5733 mL | 3.1467 mL |
| 20mM | 0.0787 mL | 0.3933 mL | 0.7867 mL | 1.5733 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.