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| Size | Price | Stock |
|---|---|---|
| 5mg | $320 | 3-6 Days |
| 10mg | $510 | 3-6 Days |
| 25mg | $900 | 3-6 Days |
| 50mg | $1620 | 3-6 Days |
| 100mg | $2530 | 3-6 Days |
: Cat #: V3254 CAS #: 1673534-76-3 Purity ≥ 99%
Description: CA-170 (also known as AUPM170 or PD-1-IN-1) is a first-in-class, potent and orally available small molecule inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1), PD-L2 and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation (programmed death 1 homolog; PD-1H). CA-170 was discovered by Curis Inc. and has potential antineoplastic activities. CA-170 selectively targets PD-L1 and VISTA, both of which function as negative checkpoint regulators of immune activation. Curis is currently investigating CA-170 for the treatment of advanced solid tumours and lymphomas in patients in a Phase 1 trial (ClinicalTrials.gov Identifier: NCT02812875). Note: Recent studies clearly showed that there is no direct binding between CA-170 and PD-L1. Therefore, proposed mechanism of the direct blocking of hPD-1/hPD-L1 interactions with CA-170 may need to be changed. Reference: Molecules. 2019 Aug 1;24(15):2804.
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| Molecular Weight (MW) | 360.3232 |
|---|---|
| Molecular Formula | C12H20N6O7 |
| CAS No. | 1673534-76-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | CA-170; CA-170; CA-170; AUPM 170; PD-1-IN-1; CA-170; Aurigene 1; CA 170 [WHO-DD]; 646MN6KQ16; (2S,3R)-2-[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]carbamoylamino]-3-hydroxybutanoic acid; L-Threonine, N-((((1S)-3-amino-1-(3-((1R)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)amino)carbonyl)-; AUPM-170; AUPM170; PD-1-IN-1;PD-1-IN 1 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7753 mL | 13.8764 mL | 27.7529 mL | 55.5057 mL |
| 5mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 11.1011 mL |
| 10mM | 0.2775 mL | 1.3876 mL | 2.7753 mL | 5.5506 mL |
| 20mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 2.7753 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.