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| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | 3-6 Days |
| 10mg | $140 | 3-6 Days |
| 25mg | $300 | 3-6 Days |
| 50mg | $410 | 3-6 Days |
| 100mg | $620 | 3-6 Days |
| 250mg | $950 | 3-6 Days |
: Cat #: V0236 CAS #: 702674-56-4 Purity ≥ 99%
Description: BX912 (BX-912) is a novel, potent and specific inhibitor of PDK-1 (phosphoinositide-dependent kinase 1) inhibitor with potential antitumor activity. In cell-free assays, it exhibits selectivity for PDK1 over PKA and PKC of 9 and 105 folds, respectively, and inhibits PDK-1 with an IC50 of 12 nM. By specifically targeting the PDK1/Akt signaling pathway, it demonstrated strong antiproliferative activity in vitro. This pathway is a promising target for anticancer medications because it is essential for the growth, survival, and angiogenesis of cancer cells.
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| Molecular Weight (MW) | 471.35 |
|---|---|
| Molecular Formula | C20H23BRN8O |
| CAS No. | 702674-56-4 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | BX 912; BX912; BX912 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1216 mL | 10.6078 mL | 21.2157 mL | 42.4313 mL |
| 5mM | 0.4243 mL | 2.1216 mL | 4.2431 mL | 8.4863 mL |
| 10mM | 0.2122 mL | 1.0608 mL | 2.1216 mL | 4.2431 mL |
| 20mM | 0.1061 mL | 0.5304 mL | 1.0608 mL | 2.1216 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.