BX-912

This product is for research use only, not for human use. We do not sell to patients.

BX-912
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1150Check With Us
500mg$1750Check With Us
1g$2625Check With Us

Cat #: V0236 CAS #: 702674-56-4 Purity ≥ 98%

Description: BX912 (BX-912) is a novel, potent and specific inhibitor of PDK-1 (phosphoinositide-dependent kinase 1) inhibitor with potential antitumor activity.

References: Feldman RI, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74.

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Product Promise

Promise
Molecular Weight (MW)471.35
Molecular FormulaC20H23BrN8O
CAS No.702674-56-4
Shipping Temperature-20℃ for 3 years in powder form -80℃ for 2 years in solvent
Solubility In VitroDMSO: 94 mg/mL (199.4 mM)r
Water: <1 mg/mLr
Ethanol: N/A
Solubility In Vivo30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL
SMILES CodeO=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(Br)C(NCCC4=CNC=N4)=N3)=C2
SynonymsBX 912; BX912; BX912
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1216 mL10.6078 mL21.2157 mL42.4313 mL
5mM0.4243 mL2.1216 mL4.2431 mL8.4863 mL
10mM0.2122 mL1.0608 mL2.1216 mL4.2431 mL
20mM0.1061 mL0.5304 mL1.0608 mL2.1216 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.