Bumetanide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $150 | Check With Us |
| 5g | $250 | Check With Us |
| 10g | $375 | Check With Us |
: Cat #: V4488 CAS #: 28395-03-1 Purity ≥ 98%
Description: Bumetanide (also known as Ro 10-6338; PF-1593) is a novel and potent inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 364.42 |
|---|---|
| Molecular Formula | C17H20N2O5S |
| CAS No. | 28395-03-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vivo | Bumetanide (7.6-30.4 mg/kg； intravenous) attenuated the reduction in the apparent diffusion coefficient (ADC) ratio of the cortex and striatum (40-67%), indicating reduced edema formation |
|---|---|---|
| Animal model | Normotensive Sprague-Dawley rats (250-300 g) | |
| Dosages | 7.6 mg/kg, 15.2 mg/kg, 30.4 mg/kg | |
| Administration | Intravenous injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7441 mL | 13.7204 mL | 27.4409 mL | 54.8817 mL |
| 5mM | 0.5488 mL | 2.7441 mL | 5.4882 mL | 10.9763 mL |
| 10mM | 0.2744 mL | 1.3720 mL | 2.7441 mL | 5.4882 mL |
| 20mM | 0.1372 mL | 0.6860 mL | 1.3720 mL | 2.7441 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.