Bufalin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $820 | Check With Us |
| 500mg | $1300 | Check With Us |
| 1g | $1950 | Check With Us |
: Cat #: V8748 CAS #: 465-21-4 Purity ≥ 99%
Description: Bufalin is a novel and potent inhibitor of steroid receptor coactivator 3 (SRC-3) with anticancer, anti-inflammatory and antinociceptive activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 386.53 |
|---|---|
| Molecular Formula | C24H34O4 |
| CAS No. | 465-21-4 |
| SMILES Code | O=C1C=CC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=CO1 |
| Synonyms | Bufalin |
| Protocol | In Vitro | Bufalin (2 μM) increased caspae-3, Endo G, and GADD153 mRNA expression but decreased GRP78 mRNA expression |
|---|---|---|
| In Vivo | Bufalin (0.1, 0.2, or 0.4 mg/kg intraperitoneally once daily for 14 days) showed significant antitumor activity in mice carrying NCI-H460 cells | |
| Animal model | Forty male athymic BALB/c nu/nu mice (6-8 weeks old) | |
| Dosages | 0.1, 0.2, or 0.4 mg/kg | |
| Administration | I.P. every day until 14 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5871 mL | 12.9356 mL | 25.8712 mL | 51.7424 mL |
| 5mM | 0.5174 mL | 2.5871 mL | 5.1742 mL | 10.3485 mL |
| 10mM | 0.2587 mL | 1.2936 mL | 2.5871 mL | 5.1742 mL |
| 20mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 2.5871 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.