Budesonide | CAS 51333-22-3

Budesonide

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
2g	$550	Check With Us
5g	$980	Check With Us
10g	$1470	Check With Us

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Cat #: V1704 CAS #: 51333-22-3 Purity ≥ 98%

Description: Budesonide (Rhinocort; Budicort; Entocort; Rhinosol; Pulmicort; Symbicort; Noex Entocort EC) is a synthetic glucocorticoid steroid approved for use in the treatment of inflammatory conditions such as asthma, non-infectious rhinitis, and nasal polyposis.

References: Liang Dong, et al. Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice. J Imm

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	430.53
Molecular Formula	C25H34O6
CAS No.	51333-22-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 86 mg/mL (199.7 mM)r
	Water:<1 mg/mLr
	Ethanol: 19 mg/mL (44.1 mM)
Synonyms	Rhinocort; Budicort; Entocort; Rhinosol; Pulmicort; Symbicort; Noex Entocort EC

Protocol	In Vitro	Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)
Protocol	In Vivo	Budesonide (0.5 mg/kg; intranasal administration 1 h before LPS injection (5 mg/kg)) pretreatment dramatically attenuates pathological injury and reduces pathological scores in mice with ALI in adult male C57BL/6 mice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3227 mL	11.6136 mL	23.2272 mL	46.4544 mL
5mM	0.4645 mL	2.3227 mL	4.6454 mL	9.2909 mL
10mM	0.2323 mL	1.1614 mL	2.3227 mL	4.6454 mL
20mM	0.1161 mL	0.5807 mL	1.1614 mL	2.3227 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.