BRIGATINIB ANALOG

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$650	Check With Us
1g	$1050	Check With Us
5g	$2660	Check With Us

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Cat #: V3921 CAS #: 1197958-12-5 Purity ≥ 98%

Description: Brigatinib analog is a derivative of Brigatinib (AP-26113; Alunbrig), which is an orally bioavailable ALK (anaplastic lymphoma kinase) inhibitor approved by FDA in 2017 for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC).

References: Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	529.01
Molecular Formula	C26H34ClN6O2P
CAS No.	1197958-12-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 45 mg/mL (85.1 mM)r
	Water: <1 mg/mLr
	Ethanol: 106 mg/mL (200.4 mM)
Solubility In Vivo	NMP+polyethylene glycol 300 (10+90, v+v): 1 mg/mL
SMILES Code	CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N(C)C)CC4)C=C3OC)=NC=C2Cl)=O
Synonyms	AP-26113; Brigatinib-analog; AP26113; AP 26113

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8903 mL	9.4516 mL	18.9032 mL	37.8065 mL
5mM	0.3781 mL	1.8903 mL	3.7806 mL	7.5613 mL
10mM	0.1890 mL	0.9452 mL	1.8903 mL	3.7806 mL
20mM	0.0945 mL	0.4726 mL	0.9452 mL	1.8903 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.