BRD7116 | CAS 329059-55-4

BRD7116

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$939	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V3480 CAS #: 329059-55-4 Purity ≥ 98%

Description: BRD7116 is a novel, potent and selective Inhibitor of leukemia stem cell (LSC) activity with EC50 of 200 nM. It exhibits >100-fold selectivity for LSCs over normal hematopoietic stem cells. Efforts to develop more effective therapies for acute leukemia may benefit from high-throughput screening systems that reflect the complex physiology of the disease, including leukemia stem cells (LSCs) and supportive interactions with the bone marrow microenvironment. The therapeutic targeting of LSCs is challenging because LSCs are highly similar to normal hematopoietic stem and progenitor cells (HSPCs) and are protected by stromal cells in vivo.

References: Hartwell KA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec;9(12):840-848

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	496.67
Molecular Formula	C28H36N2O4S
CAS No.	329059-55-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(C=C3)NC(C4C(C)(C(C)4C)C)=O)=O
Synonyms	BRD7116; BRD-7116; BRD 7116

Related Biological Data

Novel Small Molecule BRD7116 Selectively Targets LSCe Cells by Cell-Autonomous and Cell-Non-Autonomous Mechanisms. Nat Chem Biol. 2013 Dec;9(12):840-848.

Prioritized Screening Hits Display Selective Toxicity to LSCe Cells Relative to HSPCs in Co-culture.

A High-Throughput System for Probing Primary, Stem-enriched Leukemia Cells Within a Stromal Niche. Nat Chem Biol. 2013 Dec;9(12):840-848.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0134 mL	10.0670 mL	20.1341 mL	40.2682 mL
5mM	0.4027 mL	2.0134 mL	4.0268 mL	8.0536 mL
10mM	0.2013 mL	1.0067 mL	2.0134 mL	4.0268 mL
20mM	0.1007 mL	0.5034 mL	1.0067 mL	2.0134 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.