Bomedemstat ditosylate (IMG 7289)

This product is for research use only, not for human use. We do not sell to patients.

Bomedemstat ditosylate (IMG 7289)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$1203-6 Days
5mg$3103-6 Days
10mg$5203-6 Days
email: [email protected]        [email protected]

Cat #: V41352 CAS #: 1990504-72-7 Purity ≥ 99%

Description: Bomedemstat ditosylate (IMG7289) is a novel, potent and orally bioavailable small molecule discovered and developed by Imago BioSciences that inhibits lysine-specific demethylase 1 (LSD1 or KDM1A), an enzyme shown to be vital in cancer stem/progenitor cells, particularly neoplastic bone marrow cells. In non-clinical studies, bomedemstat demonstrated robust in vivo anti-tumor efficacy across a range of myeloid malignancies as a single agent and in combination with other chemotherapeutic agents. Bomedemstat is an investigational agent currently being evaluated in ongoing clinical trials (ClinicalTrials.gov Identifier: NCT03136185, NCT04262141 and NCT04081220). Bomedemstat has FDA Orphan Drug and Fast Track Designation for the treatment of myelofibrosis and essential thrombocythemia, Orphan Drug Designation for treatment of acute myeloid leukemia and PRIME designation by the European Medicines Agency for the treatment of MF.

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Molecular Weight (MW)864.016911029816
Molecular FormulaC42H50FN7O8S2
CAS No.1990504-72-7
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

SynonymsIMG7289 ditosylate; IMG-7289; IMG 7289; BOMEDEMSTAT DITOSYLATE; IMG-7289 ditosylate; 1990504-72-7; Bomedemstat tosylate; Bomedemstat (ditosylate); Bomedemstat ditosylate (IMG 7289); 2PYF2U9JNF; Bomedemstat tosylate [USAN]; Bomedemstat ditosylate
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.1574 mL5.7869 mL11.5738 mL23.1477 mL
5mM0.2315 mL1.1574 mL2.3148 mL4.6295 mL
10mM0.1157 mL0.5787 mL1.1574 mL2.3148 mL
20mM0.0579 mL0.2893 mL0.5787 mL1.1574 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.