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BMS-986176

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BMS-986176
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Cat #: V3494 CAS #: 1815613-42-3 Purity ≥ 99%

Description: BMS986176(also known as AAK1-IN-1 or LX-9211) is a highly selective, CNS penetrant, potent AAK1 inhibitor( IC50=2.2 nM).

References: Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.

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Molecular Weight (MW)385.4066
Molecular FormulaC19H23F4N3O
CAS No.1815613-42-3
SynonymsAAK1-IN-1;LX-9211; LX9211; LX 9211; BMS 986176; BMS-986176; BMS986176;
ProtocolIn VitroAdaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5947 mL12.9733 mL25.9466 mL51.8932 mL
5mM0.5189 mL2.5947 mL5.1893 mL10.3786 mL
10mM0.2595 mL1.2973 mL2.5947 mL5.1893 mL
20mM0.1297 mL0.6487 mL1.2973 mL2.5947 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.