BMS-345541 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1100 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V30197 CAS #: 547757-23-3 Purity ≥ 99%
Description: BMS-345541 HCl is a novel, cell-permeable and selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.
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| Molecular Weight (MW) | 291.78 |
|---|---|
| Molecular Formula | C14H18ClN5 |
| CAS No. | 547757-23-3 |
| SMILES Code | NCCNC1=NC2=C(N3C1=NC=C3C)C=C(C)C=C2.[H]Cl |
| Synonyms | BMS 345541; BMS-345541; BMS345541; UNII-BXU277OCN5; |
| Protocol | In Vitro | BMS-345541 inhibits IKK-2 and IKK-1 in dose-dependent manner. BMS-345541 fails to inhibit a panel of both serine/threonine and tyrosine kinases at concentrations as high as 100 μM. MS-345541 at concentrations as high as 100 μM fails to block both the anisomycin-stimulated phosphorylation of c-Jun and LPS-stimulated activation of MAPKAP K2 in THP-1 cells, as well as the EGF-stimulated phosphorylation of STAT3 in H292 cells. |
|---|---|---|
| In Vivo | BMS-345541 (10 mg/kg, p.o.) results in prolonged serum drug levels, with concentrations sustained at or above 1 μM for many hours in mice. BMS-345541 dose-dependently inhibits the production of TNFα measured in the serum of animals challenged with an intraperitoneal administration of LPS. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4272 mL | 17.1362 mL | 34.2724 mL | 68.5448 mL |
| 5mM | 0.6854 mL | 3.4272 mL | 6.8545 mL | 13.7090 mL |
| 10mM | 0.3427 mL | 1.7136 mL | 3.4272 mL | 6.8545 mL |
| 20mM | 0.1714 mL | 0.8568 mL | 1.7136 mL | 3.4272 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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