BMS-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $760 | In Stock |
| 500mg | $1350 | In Stock |
| 1g | $2025 | In Stock |
: Cat #: V3097 CAS #: 1675201-83-8 Purity ≥ 98%
Description: BMS-1 (also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) is a novel and highly potent small molecule inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 nM.
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- Related Biological Data
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| Molecular Weight (MW) | 475.58 |
|---|---|
| Molecular Formula | C29H33NO5 |
| CAS No. | 1675201-83-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 95 mg/mL (199.7 mM)r |
| Water: 95 mg/mL (199.7 mM)r | |
| Ethanol: N/A | |
| SMILES Code | O=C([C@H]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O |
| Synonyms | PD1/PDL1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD1-PDL1-IN1; BMS-1; BMS 1; BMS1 |
| Protocol | In Vitro | Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1. |
|---|---|---|
| In Vivo | BMS-1 (500 μg/mL; 100 μL; i.p.) significantly increases the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1027 mL | 10.5135 mL | 21.0270 mL | 42.0539 mL |
| 5mM | 0.4205 mL | 2.1027 mL | 4.2054 mL | 8.4108 mL |
| 10mM | 0.2103 mL | 1.0513 mL | 2.1027 mL | 4.2054 mL |
| 20mM | 0.1051 mL | 0.5257 mL | 1.0513 mL | 2.1027 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.