BIX 01294
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $920 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V0381 CAS #: 935693-62-2 (free base); Purity ≥ 98%
Description: BIX01294 is a novel and potent inhibitor of G9a histone methyltransferase with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 490.64 |
|---|---|
| Molecular Formula | C28H38N6O2 |
| CAS No. | 935693-62-2 (free base); |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 98 mg/mL (163.3 mM)r |
| Water: >10 mg/mLr | |
| Ethanol: 8 mg/mL (13.33 mM) | |
| Synonyms | BIX01294 HCl; BIX01294; BIX-01294; BIX 01294; |
| Protocol | In Vitro | BIX-01294 leads to necroptotic cell death in recurrent tumor cells. Necrostatin-1 (30 μM) partially reverses cell death induced by BIX-01294 (750 nM; 24 h). BIX-01294 (1 μM; 6 days) causes the reduction in H3K9me2 levels in primary and recurrent tumor cells. BIX-01294 (1 μM) significantly upregulates the canonical p53 targets Cdkn1a (p21) and Gadd45a in recurrent tumor cell lines. BIX-01294 (1 μM) leads to a marked increase in phosphorylation of S345 of MLKL. BIX-01294 (2 μM; 48 h) selectively inhibits recurrent tumor cell growth. |
|---|---|---|
| In Vivo | BIX-01294 (10 mg/kg; IP; three times a week for 2 weeks) significantly reduces tumor growth and tumor burden in recurrent tumor cells. Primary tumor growth is not inhibited. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0382 mL | 10.1908 mL | 20.3815 mL | 40.7631 mL |
| 5mM | 0.4076 mL | 2.0382 mL | 4.0763 mL | 8.1526 mL |
| 10mM | 0.2038 mL | 1.0191 mL | 2.0382 mL | 4.0763 mL |
| 20mM | 0.1019 mL | 0.5095 mL | 1.0191 mL | 2.0382 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.