Home > Signaling Pathways>DNA Damage>Topoisomerase >Bisantrene HCl (CL-216942, NSC-337766)
Bisantrene HCl (CL-216942, NSC-337766)

This product is for research use only, not for human use. We do not sell to patients.

Bisantrene HCl (CL-216942, NSC-337766)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1250To Be Confirmed
1g$1620To Be Confirmed
5g$24305To Be Confirmed

Cat #: V12770 CAS #: 71439-68-4 Purity ≥ 98%

Description: Bisantrene HCl (CL216942 and NSC337766), the hydrochloride salt of Bisantrene, is potent inhibitor of topoisomerase II and DNA intercalators with anticancer activity.

References: Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.d

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)471.39
Molecular FormulaC22H24Cl2N8
CAS No.71439-68-4
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1214 mL10.6069 mL21.2139 mL42.4277 mL
5mM0.4243 mL2.1214 mL4.2428 mL8.4855 mL
10mM0.2121 mL1.0607 mL2.1214 mL4.2428 mL
20mM0.1061 mL0.5303 mL1.0607 mL2.1214 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.