Bifonazole | CAS 60628-96-8

Bifonazole

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$400	Check With Us
25g	$650	Check With Us
50g	$975	Check With Us

: [email protected] [email protected]

Cat #: V4209 CAS #: 60628-96-8 Purity ≥ 98%

Description: Bifonazole ( Bifomyk; Bay H-4502; Bifokey;Bifon) is a potent imidazole-based antifungal drug with a broad-spectrum of antimycotic activity by interfering with sterol biosynthesis.

References: Berg, D. and M. Plempel, Bifonazole, a biochemist's view. Dermatologica, 1984. 169 Suppl 1: p. 3-9.

Top Publications Citing Invivochem Products

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	310.39
Molecular Formula	C22H18N2
CAS No.	60628-96-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	C1=CC=CC(=C1)C(C2=CC=C(C=C2)C3=CC=CC=C3)N4C=NC=C4
Synonyms	Bifonazole; Mycospor; Amycor; Bifonazol; Trifonazole; Moldina; Bay H 4502; Bay H-4502; Bifokey; Bifomyk; Bifon; Canesten brand of bifonazole;

Protocol	In Vitro	Bifonazole (Bay H-4502), a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase. bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase. In vitro Bifonazole (Bay H-4502) shows a strongly pH-dependent efficacy. The uptake kinetics of Bifonazole (Bay H-4502) have been measured with different pathogens.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2218 mL	16.1088 mL	32.2175 mL	64.4351 mL
5mM	0.6444 mL	3.2218 mL	6.4435 mL	12.8870 mL
10mM	0.3222 mL	1.6109 mL	3.2218 mL	6.4435 mL
20mM	0.1611 mL	0.8054 mL	1.6109 mL	3.2218 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise