BIBF-1202
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2050 | Check With Us |
| 1g | $3075 | Check With Us |
: Cat #: V12626 CAS #: 894783-71-2 Purity ≥ 98%
Description: BIBF-1202 (BIBF1202; BIBF 1202) is the carboxylate metabolite of Nintedanib (formerly BIBF-1120; Vargatef), which is an approved anticancer medication acting as an orally bioavailable triple angiokinase (VEGFR, PDGFR, FGFR) inhibitor.
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| Molecular Weight (MW) | 525.60 |
|---|---|
| Molecular Formula | C30H31N5O4 |
| CAS No. | 894783-71-2 |
| SMILES Code | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O |
| Synonyms | BIBF-1202; BIBF 1202; BIBF1202 |
| Protocol | In Vitro | The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Subsequently, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acylglucuronide. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9026 mL | 9.5129 mL | 19.0259 mL | 38.0518 mL |
| 5mM | 0.3805 mL | 1.9026 mL | 3.8052 mL | 7.6104 mL |
| 10mM | 0.1903 mL | 0.9513 mL | 1.9026 mL | 3.8052 mL |
| 20mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 1.9026 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.