BH3I-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $700 | Check With Us |
| 250mg | $1300 | Check With Us |
| 500mg | $1950 | Check With Us |
: Cat #: V12602 CAS #: 300817-68-9 Purity ≥ 99%
Description: BH3I-1 is a novel and potent Bcl-2 family inhibitor.
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| Molecular Weight (MW) | 400.31 |
|---|---|
| Molecular Formula | C15H14BrNO3S2 |
| CAS No. | 300817-68-9 |
| SMILES Code | O=C(O)C(C(C)C)N(C/1=O)C(SC1=C\C2=CC=C(Br)C=C2)=S |
| Synonyms | BH3I1; BH 3I1; BH-3I1; BH3I-1; BH 3I-1; BH-3I-1; |
| Protocol | In Vitro | BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1α interactions. This surprising promiscuity, displays by a well studied compound leads to further interrogate the p53/hDM2 interaction utilizing a standard fluorescence polarization (FP) assay with purified protein. The results from the FP assay validates the split-luciferase screen and demonstrates that BH3I-1 has a Kd=5.3 μM against the p53/mDM2 pair, which is comparable to its low micromolar potency reported for the BH3 family of receptors. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4981 mL | 12.4903 mL | 24.9806 mL | 49.9613 mL |
| 5mM | 0.4996 mL | 2.4981 mL | 4.9961 mL | 9.9923 mL |
| 10mM | 0.2498 mL | 1.2490 mL | 2.4981 mL | 4.9961 mL |
| 20mM | 0.1249 mL | 0.6245 mL | 1.2490 mL | 2.4981 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.