Betamethasone Valerate (BV; BET)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$550	Check With Us
1g	$890	Check With Us
5g	$2400	Check With Us

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Cat #: V1711 CAS #: 2152-44-5 Purity ≥ 98%

Description: Betamethasone Valerate (BV; BET; Betoid; Valison; 9α-Fluo; Valisone; Bedermin; Betneval; Beta-Val; Bextasol; Dermosol; Stanoval) is a moderately potent and commonly used glucocorticoid steroid with anti-inflammatory and immunosuppressive activities.

References: Iizuka Y, et al. Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments. Agents Actions. 1981 May;11(3):254-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	476.58
Molecular Formula	C27H37FO6
CAS No.	2152-44-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 95 mg/mL (199.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 58 mg/mL (121.7 mM)
Synonyms	BV; BET; Betoid; Valison; 9α-Fluo; Valisone; Bedermin; Betneval; Beta-Val; Bextasol; Dermosol; Stanoval; betamethasone 17-valerate; Betamethasone Valerate

Protocol	In Vivo	Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy
	Animal model	Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment)
	Dosages	10 mg
	Administration	Applied to the irritated site with a micro spatula; 5 minutes

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0983 mL	10.4914 mL	20.9828 mL	41.9657 mL
5mM	0.4197 mL	2.0983 mL	4.1966 mL	8.3931 mL
10mM	0.2098 mL	1.0491 mL	2.0983 mL	4.1966 mL
20mM	0.1049 mL	0.5246 mL	1.0491 mL	2.0983 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.