BENZNIDAZOLE (Ro 07-1051)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $350 | Check With Us |
| 2g | $600 | Check With Us |
| 5g | $1010 | Check With Us |
: Cat #: V3912 CAS #: 22994-85-0 Purity ≥ 98%
Description: Benznidazole (Ro-07-1051; NSC-299972; Radanil) is an FDA approved and orally bioavailable antiparasitic drug used in the treatment of Chagas disease.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 260.25 |
|---|---|
| Molecular Formula | C12H12N4O3 |
| CAS No. | 22994-85-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(NCC1=CC=CC=C1)CN2C=CN=C2[N+]([O-])=O |
| Synonyms | Ro 07-1051; NSC299972; Ro 71051; NSC 299972; Ro-07-1051; Ro71051; Benznidazole; NSC-299972; Radanil; |
| Protocol | In Vivo | Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole. |
|---|---|---|
| Animal model | Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 | |
| Dosages | 100 mg/kg/day | |
| Administration | Orally for 30 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8425 mL | 19.2123 mL | 38.4246 mL | 76.8492 mL |
| 5mM | 0.7685 mL | 3.8425 mL | 7.6849 mL | 15.3698 mL |
| 10mM | 0.3842 mL | 1.9212 mL | 3.8425 mL | 7.6849 mL |
| 20mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 3.8425 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.