Belizatinib | CAS 1357920-84-3;

Belizatinib

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1200	Check With Us
500mg	$1800	Check With Us
1g	$2700	Check With Us

: [email protected] [email protected]

Cat #: V2755 CAS #: 1357920-84-3; Purity ≥ 98%

Description: Belizatinib, formerly known as TSR-011, is a potent, orally bioavailable dual inhibitor of ALK (anaplastic lymphoma kinase) with IC50 of 0.7 nM and an inhibitor of tropomyosin receptor kinase (TRK) with IC50 values less than 3 nM for TRK A, B, and C.

References: Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	577.73
Molecular Formula	C33H44FN5O3
CAS No.	1357920-84-3;
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (173.1 mM)r
	Water: <1 mg/mLr
	Ethanol: 100 mg/mL (173.1 mM)
SMILES Code	O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
Synonyms	TSR-011; TSR011; TSR 011; Belizatinib

Protocol	In Vitro	TSR-011 has antitumour activity in the clinical trials.
Protocol	In Vivo	TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7309 mL	8.6546 mL	17.3091 mL	34.6182 mL
5mM	0.3462 mL	1.7309 mL	3.4618 mL	6.9236 mL
10mM	0.1731 mL	0.8655 mL	1.7309 mL	3.4618 mL
20mM	0.0865 mL	0.4327 mL	0.8655 mL	1.7309 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.