BEDAQUILINE FUMARATE

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$480	In Stock
1g	$780	In Stock
1μg	$1975	In Stock

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Cat #: V3931 CAS #: 845533-86-0 Purity ≥ 98%

Description: Bedaquiline FUMARATE (formerly also known as TMC207 and R207910; sold under the trade name Sirturo) is the FUMARATE salt of bedaquiline, which is an orally bioavailable and diarylquinoline-based anti-TB (tuberculosis) drug used specifically to treat multi-drug-resistant tuberculosis (MDR-TB) when other treatments cannot be used.

References: Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	671.59
Molecular Formula	C36H35BrN2O6
CAS No.	845533-86-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O[C@](CCN(C)C)(C1=C2C=CC=CC2=CC=C1)[C@@H](C3=CC4=CC(Br)=CC=C4N=C3OC)C5=CC=CC=C5. O=C(O)/C=C/C(O)=O
Synonyms	R207910 fumarate; TMC-207 fumarate; R-207910; TMC 207; R 207910; TMC207 fumarate; Bedaquiline fumarate; trade name: Sirturo

Related Biological Data

Distribution of MIC values for rapidly growing mycobacterial strains. The arrows represent the proposed ECOFF value for rapidly growing mycobacteria. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02627-16.

Distribution of MIC values for slowly growing mycobacterial strains. The arrows represent the proposed ECOFF value for slowly growing mycobacteria. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02627-16.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4890 mL	7.4450 mL	14.8900 mL	29.7801 mL
5mM	0.2978 mL	1.4890 mL	2.9780 mL	5.9560 mL
10mM	0.1489 mL	0.7445 mL	1.4890 mL	2.9780 mL
20mM	0.0745 mL	0.3723 mL	0.7445 mL	1.4890 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.