BB-Cl-Amidine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $2950 | To Be Confirmed |
| 1g | $3850 | To Be Confirmed |
| 20g | $9745 | To Be Confirmed |
: Cat #: V32207 CAS #: 1802637-39-3 Purity ≥ 99%
Description: BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor with potential for Canine and Feline Mammary Cancer via Activation of the Endoplasmic Reticulum Stress Pathway.
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- Related Biological Data
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| Molecular Weight (MW) | 459.97 |
|---|---|
| Molecular Formula | C26H26ClN5O |
| CAS No. | 1802637-39-3 |
| SMILES Code | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=CC=CC=C4N3)CCCNC(CCl)=N |
| Synonyms | BB-Cl-Amidine; BB-CLA; |
| Protocol | In Vitro | Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1741 mL | 10.8703 mL | 21.7405 mL | 43.4811 mL |
| 5mM | 0.4348 mL | 2.1741 mL | 4.3481 mL | 8.6962 mL |
| 10mM | 0.2174 mL | 1.0870 mL | 2.1741 mL | 4.3481 mL |
| 20mM | 0.1087 mL | 0.5435 mL | 1.0870 mL | 2.1741 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
=
Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.