BAY-2402234
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $2500 | Check With Us |
| 500mg | $4200 | Check With Us |
| 1g | $6300 | Check With Us |
: Cat #: V4172 CAS #: 2225819-06-5 Purity ≥ 98%
Description: BAY-2402234 is a novel, potent/low-nanomolar and selective inhibitor of dihydroorotate dehydrogenase (DHODH) that has the potential for the treatment of myeloid malignancies.
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| Molecular Weight (MW) | 520.84 |
|---|---|
| Molecular Formula | C21H18ClF5N4O4 |
| CAS No. | 2225819-06-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1 |
| Synonyms | BAY-2402234; BAY 2402234; BAY2402234; Orludodstat; Orludodstatum; |
| Protocol | In Vitro | BAY-2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY-2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. |
|---|---|---|
| In Vivo | BAY-2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Target engagement of the novel DHODH inhibitor BAY-2402234 can be observed by increase of tumoral and plasma dihydroorotate levels after treatment with the inhibitor. Consistent with the in vitro data BAY-2402234 induces AML differentiation in vivo as detected by upregulation of differentiation cell surface markers in xenograft and PDX models after treatment with the inhibitor. Furthermore, differentiation-associated transcriptomic changes are evident following a single administration of BAY-2402234 in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9200 mL | 9.5999 mL | 19.1998 mL | 38.3995 mL |
| 5mM | 0.3840 mL | 1.9200 mL | 3.8400 mL | 7.6799 mL |
| 10mM | 0.1920 mL | 0.9600 mL | 1.9200 mL | 3.8400 mL |
| 20mM | 0.0960 mL | 0.4800 mL | 0.9600 mL | 1.9200 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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