Bardoxolone Methyl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $800 | Check With Us |
| 5g | $2025 | Check With Us |
: Cat #: V0754 CAS #: 218600-53-4 Purity ≥ 98%
Description: Bardoxolone Methyl (also called NSC 713200; NSC-713200; RTA 402; RTA-402 and CDDO-methyl ester) is a novel, potent, orally bioavailable IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 505.69 |
|---|---|
| Molecular Formula | C32H43NO4 |
| CAS No. | 218600-53-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 21 mg/mL (41.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 4% DMSO+30% PEG 300+5% Tween+ddH2O: 5mg/mL |
| SMILES Code | O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4(C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC |
| Synonyms | NSC-713200; NSC713200; CDDO Methyl Ester; Bardoxolone methyl; CDDOMe; NSC 713200; RTA 402; RTA-402; RTA402;TP-155; TP155; TP 155 |
| Protocol | In Vivo | Bardoxolone methyl (30 mg/kg, p.o.) decreases renal expression of megalin but not cubilin, increases creatinine clearance and urinary albumin-to-creatinine ratios, and induces Nrf2 cytoprotective targets in cynomolgus monkeys. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9775 mL | 9.8875 mL | 19.7750 mL | 39.5499 mL |
| 5mM | 0.3955 mL | 1.9775 mL | 3.9550 mL | 7.9100 mL |
| 10mM | 0.1977 mL | 0.9887 mL | 1.9775 mL | 3.9550 mL |
| 20mM | 0.0989 mL | 0.4944 mL | 0.9887 mL | 1.9775 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.