Home > Product Type>PROTACs>PROTAC Linkers>Azido-PEG6-alcohol
Azido-PEG6-alcohol

This product is for research use only, not for human use. We do not sell to patients.

Azido-PEG6-alcohol
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$400Check With Us
500mg$550Check With Us
1g$825Check With Us

Cat #: V10176 CAS #: 86770-69-6 Purity ≥ 98%

Description: Azido-PEG6-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.

References: Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)307.34
Molecular FormulaC12H25N3O6
CAS No.86770-69-6
SMILES CodeOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
SynonymsAzido-PEG6-alcohol
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2537 mL16.2686 mL32.5373 mL65.0745 mL
5mM0.6507 mL3.2537 mL6.5075 mL13.0149 mL
10mM0.3254 mL1.6269 mL3.2537 mL6.5075 mL
20mM0.1627 mL0.8134 mL1.6269 mL3.2537 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.