Azido-PEG4-acid
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $800 | To Be Confirmed |
| 25g | $1450 | To Be Confirmed |
| 50g | $2175 | To Be Confirmed |
: Cat #: V12194 CAS #: 1257063-35-6 Purity ≥ 99%
Description: Azido-PEG4-acid is a PEG analogue containing an azide group and is used as a PROTAC linker for the synthesis of Rucaparib-based PARP PROTAC degraders.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 291.30 |
|---|---|
| Molecular Formula | C11H21N3O6 |
| CAS No. | 1257063-35-6 |
| SMILES Code | OC(CCOCCOCCOCCOCCN=[N+]=[N-])=O |
| Synonyms | Azido-PEG4-acid |
| Protocol | In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4329 mL | 17.1644 mL | 34.3289 mL | 68.6577 mL |
| 5mM | 0.6866 mL | 3.4329 mL | 6.8658 mL | 13.7315 mL |
| 10mM | 0.3433 mL | 1.7164 mL | 3.4329 mL | 6.8658 mL |
| 20mM | 0.1716 mL | 0.8582 mL | 1.7164 mL | 3.4329 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.