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Azido-PEG2-CH2CO2H

This product is for research use only, not for human use. We do not sell to patients.

Azido-PEG2-CH2CO2H
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$550Check With Us
500mg$750Check With Us
1g$1125Check With Us

Cat #: V12180 CAS #: 882518-90-3 Purity ≥ 98%

Description: Azido-PEG2-CH2CO2H is a PEG analogue containing an azide group with a terminal carboxylic acid.

References: Yimin Qian, et al. Composés et procédés pour la dégradation ciblée de protéines contenant un bromodomaine. WO2017030814A1.

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Product Promise

Promise
Molecular Weight (MW)189.17
Molecular FormulaC6H11N3O4
CAS No.882518-90-3
SMILES CodeOC(COCCOCCN=[N+]=[N-])=O
SynonymsAzido-PEG2-CH2CO2H
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM5.2863 mL26.4313 mL52.8625 mL105.7250 mL
5mM1.0573 mL5.2863 mL10.5725 mL21.1450 mL
10mM0.5286 mL2.6431 mL5.2863 mL10.5725 mL
20mM0.2643 mL1.3216 mL2.6431 mL5.2863 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.