Azido-PEG2-amine

This product is for research use only, not for human use. We do not sell to patients.

Azido-PEG2-amine
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$280Check With Us
2g$380Check With Us
5g$640Check With Us

Cat #: V6159 CAS #: 166388-57-4 Purity ≥ 98%

Description: Azido-PEG2-amine is a PEG analogue containing an amino group with an azide group.

References: Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.

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Molecular Weight (MW)174.20
Molecular FormulaC6H14N4O2
CAS No.166388-57-4
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM5.7405 mL28.7026 mL57.4053 mL114.8106 mL
5mM1.1481 mL5.7405 mL11.4811 mL22.9621 mL
10mM0.5741 mL2.8703 mL5.7405 mL11.4811 mL
20mM0.2870 mL1.4351 mL2.8703 mL5.7405 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.