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| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | 3-6 Days |
| 10mg | $140 | 3-6 Days |
| 25mg | $220 | 3-6 Days |
| 50mg | $330 | 3-6 Days |
| 100mg | $470 | 3-6 Days |
| 250mg | $680 | 3-6 Days |
| 500mg | $960 | 3-6 Days |
: Cat #: V3257 CAS #: 878385-84-3 Purity ≥ 99%
Description: AZD-5069 (AZD5069) is a novel and potent CXCR2 chemokine receptor antagonist with potential anticancer and antiinflammatory activities. The proliferation and progression of tumor cells are facilitated by the upregulation of the CXC chemokine receptor CXCR2 in a range of distinct tumor cell types. Reduced tumorigenesis and metastasis were the results of CXCR2 inhibition. At a pIC50 of 9.1, AZD-5069 prevents radiolabeled CXCL8 from binding to human CXCR2. In phase Ib/II studies, AZD5069, an antagonist of CXCR2, is presently being studied in combination with tremelimumab for patients with metastatic squamous cell carcinoma of the head and neck and advanced solid tumors. AZD-5069 has the potential to treat individuals suffering from COPD and other inflammatory diseases.
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| Molecular Weight (MW) | 476.51 |
|---|---|
| Molecular Formula | C18H22F2N4O5S2 |
| CAS No. | 878385-84-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | AZD 5069; AZD-5069; AZD5069 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0986 mL | 10.4930 mL | 20.9859 mL | 41.9718 mL |
| 5mM | 0.4197 mL | 2.0986 mL | 4.1972 mL | 8.3944 mL |
| 10mM | 0.2099 mL | 1.0493 mL | 2.0986 mL | 4.1972 mL |
| 20mM | 0.1049 mL | 0.5246 mL | 1.0493 mL | 2.0986 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.