AZD3514
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V1766 CAS #: 1240299-33-5 Purity ≥ 98%
Description: AZD3514 (AZD-3514; AZD 3514) is a novel, potent and orally bioavailable androgen receptor downregulator with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 519.56 |
|---|---|
| Molecular Formula | C25H32F3N7O2 |
| CAS No. | 1240299-33-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (192.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 100 mg/mL (192.5 mM) | |
| Synonyms | AZD3514; AZD 3514; AZD-3514. |
| Protocol | In Vitro | AZD3514 (0-10 μM/L; 24 h) inhibits the ligand-driven expression of known AR-regulated genes |
|---|---|---|
| In Vivo | AZD3514 (50-100 mg/kg; p.o. once daily for 3 days) significantly reduces nuclear AR protein in vivo | |
| Animal model | Intact or castrat 42- and 49-day-old Hans Wistar rats | |
| Dosages | 10, 50 and 100 mg/kg | |
| Administration | Oral gavage; 10-100 mg/kg once daily; for 6 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9247 mL | 9.6235 mL | 19.2471 mL | 38.4941 mL |
| 5mM | 0.3849 mL | 1.9247 mL | 3.8494 mL | 7.6988 mL |
| 10mM | 0.1925 mL | 0.9624 mL | 1.9247 mL | 3.8494 mL |
| 20mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 1.9247 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.