AZD3229 Tosylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | To Be Confirmed |
| 250mg | $2050 | To Be Confirmed |
| 500mg | $3075 | To Be Confirmed |
: Cat #: V4154 CAS #: 2248003-71-4 Purity ≥ 98%
Description: AZD3229 Tosylate, the tosylate salt of AZD-3229, is a novel, potent, pan-KIT mutant inhibitor with antitumor activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 651.71 |
|---|---|
| Molecular Formula | C31H34FN7O6S |
| CAS No. | 2248003-71-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5 |
| Synonyms | AZD3229 Tosylate; AZD-3229 Tosylate; AZD 3229 Tosylate |
| Protocol | In Vitro | AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5344 mL | 7.6721 mL | 15.3442 mL | 30.6885 mL |
| 5mM | 0.3069 mL | 1.5344 mL | 3.0688 mL | 6.1377 mL |
| 10mM | 0.1534 mL | 0.7672 mL | 1.5344 mL | 3.0688 mL |
| 20mM | 0.0767 mL | 0.3836 mL | 0.7672 mL | 1.5344 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.