AZ7550
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1350 | To Be Comfirmed |
| 250mg | $2188 | To Be Comfirmed |
| 500mg | $3282 | To Be Comfirmed |
: Cat #: V4280 CAS #: 1421373-99-0 Purity ≥ 98%
Description: AZ7550 (AZ-7550; AZ 7550) is an active metabolite of AZD-9291 (Osimertinib, a marketed anticancer drug) which inhibits the activity of IGF1R with an IC50 of 1.6 μM.
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| Molecular Weight (MW) | 485.58 |
|---|---|
| Molecular Formula | C₂₇H₃₁N₇O₂ |
| CAS No. | 1421373-99-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | CNCCN(C)c1cc(OC)c(Nc2nccc(n2)c3cn(C)c4ccccc34)cc1NC(=O)C=C |
| Synonyms | AZ7550; AZ-7550; AZ 7550; Osimertinib metabolite M3 |
| Protocol | In Vitro | AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0594 mL | 10.2970 mL | 20.5939 mL | 41.1879 mL |
| 5mM | 0.4119 mL | 2.0594 mL | 4.1188 mL | 8.2376 mL |
| 10mM | 0.2059 mL | 1.0297 mL | 2.0594 mL | 4.1188 mL |
| 20mM | 0.1030 mL | 0.5148 mL | 1.0297 mL | 2.0594 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.