AZ31

This product is for research use only, not for human use. We do not sell to patients.

AZ31
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Size Price Stock
250mg$1350Check With Us
500mg$1950Check With Us
1g$2925Check With Us

Cat #: V3683 CAS #: 2088113-98-6 Purity ≥ 98%

Description: AZ31 (AZ-31; AZ 31) is a novel, potent and orally bioavailable and BBB (blood-brain barrier)-penetreable ATM inhibitor with antitumor activity.

References: Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647.

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Product Promise

Promise
Molecular Weight (MW)420.51
Molecular FormulaC24H28N4O3
CAS No.2088113-98-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: NAr
Ethanol: NA
SynonymsAZ31; AZ-31; AZ 31
ProtocolIn VitroAZ31 (0.3-3 μM; 1 h) affects phosphorylation of a panel of ATM targets
In VivoAZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage
Animal modelNude mice
Dosages50 and 100 mg/kg
AdministrationOral gavage; 50 and 100 mg/kg twice a day
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3781 mL11.8903 mL23.7806 mL47.5613 mL
5mM0.4756 mL2.3781 mL4.7561 mL9.5123 mL
10mM0.2378 mL1.1890 mL2.3781 mL4.7561 mL
20mM0.1189 mL0.5945 mL1.1890 mL2.3781 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.