Avibactam (NXL-104)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1950 | Check With Us |
| 500mg | $3250 | Check With Us |
| 1g | $4875 | Check With Us |
: Cat #: V33636 CAS #: 1192500-31-4 Purity ≥ 99%
Description: Avibactam (NXL104; NXL-104; Avycaz) is a novel, covalent but reversible inhibitor of β-lactamase belonging to the the non-β-lactam antibiotic, inhibiting β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 265.24 |
|---|---|
| Molecular Formula | C7H11N3O6S |
| CAS No. | 1192500-31-4 |
| SMILES Code | NC([C@@H]1CC[C@@H]2CN1C(N2OS(=O)(O)=O)=O)=O |
| Synonyms | NXL-104; NXL104; NXL 104; Avibactam Free Acid; |
| Protocol | In Vitro | Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. |
|---|---|---|
| In Vivo | Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model. | |
| Animal model | Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7702 mL | 18.8509 mL | 37.7017 mL | 75.4034 mL |
| 5mM | 0.7540 mL | 3.7702 mL | 7.5403 mL | 15.0807 mL |
| 10mM | 0.3770 mL | 1.8851 mL | 3.7702 mL | 7.5403 mL |
| 20mM | 0.1885 mL | 0.9425 mL | 1.8851 mL | 3.7702 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.