Atopaxar
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1600 | To Be Confirmed |
| 250mg | $2400 | To Be Confirmed |
| 500mg | $3600 | To Be Confirmed |
: Cat #: V6725 CAS #: 751475-53-3 Purity ≥ 98%
Description: Atopaxar, formerly known as E5555, is a potent and orally -active PAR-1 inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 527.63 |
|---|---|
| Molecular Formula | C29H38FN3O5 |
| CAS No. | 751475-53-3 |
| Protocol | In Vitro | Atopaxar (0.0001-10 μM; 1h) inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC50 of 0.019 μM |
|---|---|---|
| In Vivo | Atopaxar (30-100 mg/kg; p.o.) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model | |
| Animal model | Guinea pigs, PIT model | |
| Dosages | Oral administration | |
| Administration | 10 mg/kg, 30 mg/kg, 100 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8953 mL | 9.4763 mL | 18.9527 mL | 37.9054 mL |
| 5mM | 0.3791 mL | 1.8953 mL | 3.7905 mL | 7.5811 mL |
| 10mM | 0.1895 mL | 0.9476 mL | 1.8953 mL | 3.7905 mL |
| 20mM | 0.0948 mL | 0.4738 mL | 0.9476 mL | 1.8953 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.