ATF6-activator-147 (AA147)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $580 | Check With Us |
| 250mg | $1150 | Check With Us |
| 500mg | $1725 | Check With Us |
: Cat #: V7475 CAS #: 393121-74-9 Purity ≥ 99%
Description: AA147 is an ATF6 simulator.
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- Related Biological Data
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| Molecular Weight (MW) | 255.31 |
|---|---|
| Molecular Formula | C16H17NO2 |
| CAS No. | 393121-74-9 |
| SMILES Code | O=C(CCC1=CC=CC=C1)NC2=CC(C)=CC=C2O |
| Synonyms | AA147; AA 147; AA-147 |
| Protocol | In Vitro | AA147 (10 μM; 16 h) induces NRF2-dependent upregulation of oxidative stress response genes in HT22 cells. AA147 (10 μM; 16 h) covalently modifies KEAP1 to promote NRF2 activation in HT22 cells. AA147 (20-0.078 μM (dilution in half); 6 or 16 h) protects against glutamate-induced oxidative toxicity in HT22 cells by decreasing the reactive oxygen species (ROS)-associated damage. |
|---|---|---|
| In Vivo | AA147 (intrathecal injection; single for 3 days) can rebalance XBP1s expression in severe SMA-like mice by activating ATF6, and also induce survival motor neuron expression and spinal motorneuron protection. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9168 mL | 19.5840 mL | 39.1681 mL | 78.3361 mL |
| 5mM | 0.7834 mL | 3.9168 mL | 7.8336 mL | 15.6672 mL |
| 10mM | 0.3917 mL | 1.9584 mL | 3.9168 mL | 7.8336 mL |
| 20mM | 0.1958 mL | 0.9792 mL | 1.9584 mL | 3.9168 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.