Atamparib (RBN-2397)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1100 | Check With Us |
| 100mg | $1700 | Check With Us |
| 200mg | $2550 | Check With Us |
: Cat #: V38922 CAS #: 2381037-82-5 Purity ≥ 99%
Description: Atamparib (RBN-2397; RBN2397) is a first-in-class, potent, orally bioactive and NAD+ competitive inhibitor of PARP7 (IC50<3 nM) with antitumor and immunomodulatory effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 523.43 |
|---|---|
| Molecular Formula | C20H23F6N7O3 |
| CAS No. | 2381037-82-5 |
| Protocol | In Vitro | RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells |
|---|---|---|
| In Vivo | RBN-2397 (oral administration; 3-100 mg/kg; once daily; 24-32 days) induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice | |
| Animal model | CB17 SCID mice with NCI-H1373 xenografts | |
| Dosages | 3 mg/kg, 10mg/kg, 30 mg/kg, 100 mg/kg | |
| Administration | Oral administration; once daily; 24-32 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9105 mL | 9.5524 mL | 19.1048 mL | 38.2095 mL |
| 5mM | 0.3821 mL | 1.9105 mL | 3.8210 mL | 7.6419 mL |
| 10mM | 0.1910 mL | 0.9552 mL | 1.9105 mL | 3.8210 mL |
| 20mM | 0.0955 mL | 0.4776 mL | 0.9552 mL | 1.9105 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.