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Ataluren (PTC124)

This product is for research use only, not for human use. We do not sell to patients.

Ataluren (PTC124)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$560Check With Us
1g$850Check With Us
5g$2295Check With Us
email: [email protected]        [email protected]

Cat #: V1688 CAS #: 775304-57-9 Purity ≥ 98%

Description: Ataluren (formerly known as PTC 124; PTC-124; PTC124; trade name Translarna) is a novel, potent and orally bioavailable CFTR-G542X nonsense allele inhibitor that has been approved as a medication for the treatment of Duchenne muscular dystrophy.

References: Welch EM, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature, 2007, 447(7140), 87-91.

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Molecular Weight (MW)284.24
Molecular FormulaC15H9FN2O3
CAS No.775304-57-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 57 mg/mL (200.5 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
Solubility In Vivo1% DMSO+30% polyethylene glycol+1% Tween 80: 30mg/mL
SynonymsPTC124; Ataluren; PTC 124; PTC-124
ProtocolIn VitroAtaluren (PTC124)-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons
In VivoAtaluren (PTC124) activity, optimized using nonsense-containing reporters, promotes dystrophin production in primary muscle cells from humans and mdx mice expressing dystrophin nonsense alleles, and rescues striated muscle function in mdx mice within 2-8 weeks of drug exposure. Ataluren (PTC124) is well tolerated in animals at plasma exposures substantially in excess of those required for nonsense suppression
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.5182 mL17.5908 mL35.1815 mL70.3631 mL
5mM0.7036 mL3.5182 mL7.0363 mL14.0726 mL
10mM0.3518 mL1.7591 mL3.5182 mL7.0363 mL
20mM0.1759 mL0.8795 mL1.7591 mL3.5182 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.