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ASTX029

This product is for research use only, not for human use. We do not sell to patients.

ASTX029
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1200Check With Us
500mg$2000Check With Us
1g$3000Check With Us
email: [email protected]        [email protected]

Cat #: V3493 CAS #: 2095719-92-7 Purity ≥ 99%

Description: ASTX-029(also known as ERK1/2 inhibitor 2) is a highly potent and selective dual-mechanism ERK inhibitor.

References: Michael Reader, et al. 6-pyrimidin-isoindole derivative as erk1/2 inhibitor. WO2018193410A1.

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Molecular Weight (MW)584.04
Molecular FormulaC29H31ClFN5O5
CAS No.2095719-92-7
SMILES CodeClC(C(C1=CC=C2C(C(N([C@H](C)C(N[C@H](CO)C3=CC(OC)=CC(F)=C3)=O)C2)=O)=C1)=N4)=CN=C4NC5CCOCC5
SynonymsASTX-029; ASTX029; ASTX 029;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7122 mL8.5611 mL17.1221 mL34.2442 mL
5mM0.3424 mL1.7122 mL3.4244 mL6.8488 mL
10mM0.1712 mL0.8561 mL1.7122 mL3.4244 mL
20mM0.0856 mL0.4281 mL0.8561 mL1.7122 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.