Astemizole
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | To Be Confirmed |
| 500mg | $750 | To Be Confirmed |
| 1g | $1125 | To Be Confirmed |
: Cat #: V4935 CAS #: 68844-77-9 Purity ≥ 98%
Description: Astemizole (formerly R-43512; Hismanal) is a novel, potent and second-generation antihistamine drug with a long duration of action and is used to diminish allergic symptomsby acting as a histamine H1-receptor antagonist (IC50 = 4 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 458.57 |
|---|---|
| Molecular Formula | C28H31FN4O |
| CAS No. | 68844-77-9 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent |
| Protocol | In Vivo | Astemizole (po, 10 and 30 mg/kg) and (iv, 1 and 3 mg/kg) had no effect on respiration rate, heart rate, and blood pressure, and even at high doses of 30 mg/kg and 3 mg/kg, there was no effect on body temperature and exercise capacity in male common marmosets. However, Astemizole prolongs the QT interval and induces premature ventricular beats at 30 mg/kg (po) and 1 mg/kg (iv) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1807 mL | 10.9035 mL | 21.8069 mL | 43.6138 mL |
| 5mM | 0.4361 mL | 2.1807 mL | 4.3614 mL | 8.7228 mL |
| 10mM | 0.2181 mL | 1.0903 mL | 2.1807 mL | 4.3614 mL |
| 20mM | 0.1090 mL | 0.5452 mL | 1.0903 mL | 2.1807 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.