ASN007

This product is for research use only, not for human use. We do not sell to patients.

ASN007
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
250mg$2150Check With Us
500mg$3225Check With Us

Cat #: V41199 CAS #: 2055597-12-9 Purity ≥ 99%

Description: ASN007 (ASN-007) is a novel, potent, orally bioavailable and selective inhibitor of ERK1/2 with robust antitumor activity.

References: Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

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Promise
Molecular Weight (MW)473.93
Molecular FormulaC22H25ClFN7O2
CAS No.2055597-12-9
SMILES CodeCC1=CN=C(NC2CCOCC2)N=C1N3C=NC(C(N[C@H](CN)C4=CC(F)=CC(Cl)=C4)=O)=C3 
SynonymsASN007; ASN-007; ASN 007;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1100 mL10.5501 mL21.1002 mL42.2003 mL
5mM0.4220 mL2.1100 mL4.2200 mL8.4401 mL
10mM0.2110 mL1.0550 mL2.1100 mL4.2200 mL
20mM0.1055 mL0.5275 mL1.0550 mL2.1100 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.