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Size | Price | Stock |
---|---|---|
500mg | $290 | Check With Us |
1g | $480 | Check With Us |
5g | $810 | Check With Us |
Cat #: V1936 CAS #: 104987-12-4 Purity ≥ 98%
Description: Ascomycin (also known as FK520, FR 900520, Immunomycin), a natural product isolated from Streptomyces, is an ethyl analog of tacrolimus (FK506) and a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant.
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Molecular Weight (MW) | 792.01 |
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Molecular Formula | C43H69NO12 |
CAS No. | 104987-12-4 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 100 mg/mL (126.3 mM)r |
Water: <1 mg/mLr | |
Ethanol: 100 mg/mL (126.3 mM) | |
SMILES Code | O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O |
Synonyms | FR 900520, FK-520; FK-520; FK-520; FR900520; FR-900520; FR-900520; L 683590; L-683590; L683590; Changchuanmycin; Immunomycin |
Protocol | In Vitro | Ascomycin (FR-900520) suppresses immune response in vitro with an IC50 value of 0.55 nM for mouse mixed lymphocyte reaction. |
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In Vivo | Ascomycin (FR-900520; i.m.; 0.32-32 mg/kg; 5 days a week; for 2 weeks) clearly prolongs skin allograft survival in rats. |
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 1.2626 mL | 6.3131 mL | 12.6261 mL | 25.2522 mL |
5mM | 0.2525 mL | 1.2626 mL | 2.5252 mL | 5.0504 mL |
10mM | 0.1263 mL | 0.6313 mL | 1.2626 mL | 2.5252 mL |
20mM | 0.0631 mL | 0.3157 mL | 0.6313 mL | 1.2626 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.