ARRY-380 analog

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1240	Check With Us
500mg	$1750	Check With Us
1g	$2625	Check With Us

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Cat #: V2759 CAS #: 937265-83-3 Purity ≥ 98%

Description: ARRY-380 analog, an analog of ARRY-380 (Irbinitinib, formerly known as ARRY-380 and ONT-380 or Tucatinib) which is a potent and selective small molecule inhibitor of HER2 with IC50 value of 8 nM, it is equally potent against truncated p95-HER2, and is 500-fold more selective for HER2 versus EGFR.

References: Zaneta Nikolovska-Coleska, et al. Small molecule inhibitors of mcl-1 and uses thereof. WO2015153959A2.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	569.63
Molecular Formula	C29H27N7O4S
CAS No.	937265-83-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (175.55 mM)r
	Water: <1 mg/mLr
	Ethanol: 3 mg/mL (5.26 mM)
SMILES Code	CC1=CC(NC2=C3C=C(C4=CC=C(CNCCS(=O)(C)=O)O4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6 C=C5
Synonyms	Irbinitinib analog; Tucatinib analog; ARRY-380 analog; ONT380 analog; ONT 380 analog; ONT-380 analog

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7555 mL	8.7776 mL	17.5553 mL	35.1105 mL
5mM	0.3511 mL	1.7555 mL	3.5111 mL	7.0221 mL
10mM	0.1756 mL	0.8778 mL	1.7555 mL	3.5111 mL
20mM	0.0878 mL	0.4389 mL	0.8778 mL	1.7555 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.