ARN14974
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | To Be Confirmed |
| 500mg | $1850 | To Be Confirmed |
| 1g | $2775 | To Be Confirmed |
: Cat #: V3381 CAS #: 1644158-57-5 Purity ≥ 98%
Description: ARN14974 (ARN-14974), a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50 of 79 nM.
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- Related Biological Data
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| Molecular Weight (MW) | 404.43 |
|---|---|
| Molecular Formula | C24H21FN2O3 |
| CAS No. | 1644158-57-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(N1C(OC2=CC(C3=CC=C(F)C=C3)=CC=C12)=O)NCCCCC4=CC=CC=C4 |
| Synonyms | ARN14974; ARN-14974; ARN 14974; Acid Ceramidase Inhibitor 17a; |
| Protocol | In Vitro | ARN14974 (20 μM; 24 hours; SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels. |
|---|---|---|
| In Vivo | ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively. ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4726 mL | 12.3631 mL | 24.7262 mL | 49.4523 mL |
| 5mM | 0.4945 mL | 2.4726 mL | 4.9452 mL | 9.8905 mL |
| 10mM | 0.2473 mL | 1.2363 mL | 2.4726 mL | 4.9452 mL |
| 20mM | 0.1236 mL | 0.6182 mL | 1.2363 mL | 2.4726 mL |
The molarity calculator equation
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.