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Arfolitixorin

This product is for research use only, not for human use. We do not sell to patients.

Arfolitixorin
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Cat #: V5028 CAS #: 31690-11-6 (free) Purity ≥ 98%

Description: Arfolitixorin, an intravenously administered folate-based compound, is a novel and potent antifolate modulator that is being developed by Isofol Medical AB, for the treatment of cancer. Arfolitixorin, [6R]-5,10-methylene-tetrahydrofolic acid, is being developed to increase the efficacy of 5-FU, which has been shown to be a cytotoxic agent, as well as a rescue drug after methotrexate treatment. Arfolitixorin is the key active metabolite in leucovorin and levoleucovorin and does not require metabolic activation to exert effect.

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CAS No.31690-11-6 (free)
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.