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| Size | Price | Stock |
|---|---|---|
| 25mg | $90 | 3-6 Days |
| 50mg | $140 | 3-6 Days |
| 100mg | $250 | 3-6 Days |
| 250mg | $400 | 3-6 Days |
| 500mg | $570 | 3-6 Days |
: Cat #: V0221 CAS #: 487021-52-3 Purity ≥ 99%
Description: AR-A014418 (AR 0133418; SN4521; GSK-3 inhibitor VIII; AR 014418) is a brand-new, potent, ATP-competitive, and selective GSK3 (Glycogen Synthase Kinase 3) inhibitor with potential for treating neurodegenerative diseases. In cell-free assays, it inhibits GSK3β with an IC50 and Ki of 104 nM and 38 nM, respectively, and has minimal effects on the 26 other kinases that were also tested. By preventing Notch1 expression through inhibition of GSK-3-mediated Notch1 expression, AR-A014418 also demonstrated strong antiproliferative activity in vitro in the treatment of pancreatic cancer cells.
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| Molecular Weight (MW) | 308.3131 |
|---|---|
| Molecular Formula | C12H12N4O4S |
| CAS No. | 487021-52-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | GSK-3β Inhibitor VIII; GSK-3beta Inhibitor VIII; SN 4521; SN-4521; SN4521; AR-A014418; AR-A 014418; AR-A-014418; AR-AO-14418; 487021-52-3; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2435 mL | 16.2173 mL | 32.4346 mL | 64.8691 mL |
| 5mM | 0.6487 mL | 3.2435 mL | 6.4869 mL | 12.9738 mL |
| 10mM | 0.3243 mL | 1.6217 mL | 3.2435 mL | 6.4869 mL |
| 20mM | 0.1622 mL | 0.8109 mL | 1.6217 mL | 3.2435 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.