APS-2-79 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $629 | Check With Us |
| 500mg | $899 | Check With Us |
| 1g | $1349 | Check With Us |
: Cat #: V2664 CAS #: 2002381-31-7 Purity ≥ 98%
Description: APS-2-79 HCl (APS279 HCl; APS-279), the hydrochloride salt of APS-2-79, is an antagonist of MAPK (mitogen-activated protein kinase) with anticancer effects.
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| Molecular Weight (MW) | 423.89 |
|---|---|
| Molecular Formula | C23H21N3O3.HCl |
| CAS No. | 2002381-31-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 97 mg/mL (228.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 32 mg/mL (75.5 mM) | |
| SMILES Code | CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.[H]Cl |
| Synonyms | APS-2-79 HCl; APS279 HCl; APS2-79 HCl; APS-279 HCl; APS 2-79 HCl; APS 279 HCl |
| Protocol | In Vitro | APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutations. APS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3591 mL | 11.7955 mL | 23.5910 mL | 47.1821 mL |
| 5mM | 0.4718 mL | 2.3591 mL | 4.7182 mL | 9.4364 mL |
| 10mM | 0.2359 mL | 1.1796 mL | 2.3591 mL | 4.7182 mL |
| 20mM | 0.1180 mL | 0.5898 mL | 1.1796 mL | 2.3591 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.