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: Cat #: V33310 CAS #: 1295353-98-8 Purity ≥ 99%
Description: Apraglutide (FE-203799) is a novel 33-amino-acid peptide and GLP-2 analogue which is synthetic and long-acting. The subcutaneous GLP-2 analogue, FE, enhanced intestinal adaptation in a neonatal model of SBS without ileum. The observed intestinal lengthening with FE treatment was unique compared with our prior experience with native GLP-2 in this same model and has important clinical implications for treating neonatal SBS. At this developmental stage, growth in the intestine, if augmented, could accelerate weaning from parenteral nutrition.Glucagon-like peptide-2 (GLP-2) is an intestinotrophic factor released from L-cells in the ileum, a segment commonly resected or atretic in neonatal short bowel syndrome (SBS).
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| Molecular Weight (MW) | 3765.25 |
|---|---|
| Molecular Formula | C₁₇₂H₂₆₃N₄₃O₅₂ |
| CAS No. | 1295353-98-8 |
| Synonyms | FE 203799 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.2656 mL | 1.3279 mL | 2.6559 mL | 5.3117 mL |
| 5mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.0623 mL |
| 10mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.5312 mL |
| 20mM | 0.0133 mL | 0.0664 mL | 0.1328 mL | 0.2656 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.